activity-1

Epitope matching

The likelihood of transplantation success is strongly correlated with the degree of HLA class I and class II epitope similarity between donors and recipient. The aim of the activity is to determine the frequency of HLA class I and class II epitopes in the Canadian population. This will aid in optimizing transplantation success. 

Activity 2

Immune monitoring

Uremia is accompanied by profound disturbance of the immune response comprising both impaired immune defence and enhanced inflammation. The resulting changes in expression of cytokine, chemokine and other genes gradually recover after transplantation though the timing, extent and diversity of recovery vary widely between subjects and may be related to ethnicity, genetic polymorphisms, age, co-morbid disease and prior antigenic exposure. 

Activity 3

Personalized immuno-suppression

The aim of this study is to develop a systems pharmacology model to precisely predict individual immunosuppressive needs and to guide therapy in renal transplantation. This study evaluates a large renal transplant population under continuous longitudinal care, receiving rigorously standardized clinical management including pre-transplant management, donor/recipient HLA matching, immune suppression, viral prophylaxis and monitoring, and other aspects of clinical treatment.

 


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