"Clinical management and burden of cytomegalovirus in D+/R-Kidney transplant recipients in Canada" was published in the section of Alloimmunity and Transplantation of Frontiers in Immunology.
Purpose: To document prophylactic practices, infection patterns, and disease burden to inform strategies for CMV management in high-risk kidney transplant recipients.
Conclusion: Current prophylaxis strategies fail to prevent CMV infection in 34% of high-risk patients. Myelotoxicity, opportunistic infection, reduced immunosuppression, and hospitalization remain common and serious complications. More effective and less toxic personalized treatment strategies are required to minimize these risks and burdens.